Pyrimidines are the key skeletons in numerous bioactive compounds and natural products. A pyrimidine has many properties,
electrophilic aromatic substitution gets more difficult while nucleophilic aromatic...
substitution gets easier. In particular,
a variety of pyrimidine-derived drugs have demonstrated interesting biological activities such as cyclin-dependent kinases (CDK),
tumor necrosis factor α (TNF-α), ableson protein tyrosine kinase (Abl), 3-phosphatidylinositol kinases (PI-3K), protein kinase B (Akt kinase),
cytokines inhibitors[1, 3] and so on[4-7]. Over a century, pyrimidine derivatives are important azaheterocycles that have inspired the development of new methodologies for their chemical synthesis.