The pyrazine unit is an important structural motif that widely existed in many bioactive and nature compounds.
Pyrazine derivatives have attracted wide pharmaceutical interests because of their potential uses...
in the treatment of psychiatric disorders,
neurological diseases (e.g., stress, anxiety and depression), and cardiovascular disorders.
They are reported to modulate the activity of CRF1 (corticotropin-releasing factor 1) receptors. Besides, they are also versatile building blocks in the synthesis of
VCAM-1 (vascular cell adhesion molecule-1) inhibitors, pyrazine alkaloids (antineoplasmic activity), and imidazopyrazin coelenterazine (bioluminescent).
 In recent years, pyrazine scaffold has been found in more and more drug molecules.[3-7]