最新药物分子砌块-2020/11
The pyrazine unit is an important structural motif that widely existed in many bioactive and nature compounds.[1]
Pyrazine derivatives have attracted wide pharmaceutical interests because of their potential uses...
in the treatment of psychiatric disorders,
neurological diseases (e.g., stress, anxiety and depression), and cardiovascular disorders.[2]
They are reported to modulate the activity of CRF1 (corticotropin-releasing factor 1) receptors. Besides, they are also versatile building blocks in the synthesis of
VCAM-1 (vascular cell adhesion molecule-1) inhibitors, pyrazine alkaloids (antineoplasmic activity), and imidazopyrazin coelenterazine (bioluminescent).
[2] In recent years, pyrazine scaffold has been found in more and more drug molecules.[3-7]