Pyrimidines are the key skeletons in numerous bioactive compounds and natural products^[1]. A pyrimidine has many properties, electrophilic aromatic substitution gets more difficult while nucleophilic aromatic...
substitution gets easier^[2]. In particular, a variety of pyrimidine-derived drugs have demonstrated interesting biological activities such as cyclin-dependent kinases (CDK), tumor necrosis factor α (TNF-α), ableson protein tyrosine kinase (Abl), 3-phosphatidylinositol kinases (PI-3K), protein kinase B (Akt kinase), cytokines inhibitors^{[1, 3]} and so on^[4-7]. Over a century, pyrimidine derivatives are important azaheterocycles that have inspired the development of new methodologies for their chemical synthesis[2].

In the last few years, increasing attention has been paid to the imidazo
[1,5-a]pyridine nucleus^[1]. The imidazo[1,5-a]pyridines are an important class of heterocyclic compounds owing to their photophysical and...
biological properties. They have found utility in a number of areas of research including potential applications in organic light-emitting diodes (OLED) and thin-layer field effect transistors (FET). In addition they have been investigated in a wide range of potential pharmaceutical applications, including HIV-protease inhibitors, and Thromboxane A2 synthesis inhibitors^[2-6].