Cyclobutane derivatives, as molecular building blocks, has gained increasing importance. They can be used as starting materials for the synthesis of both acyclic and cyclic systems,including carbo- and heterobicyclic and oligocylic compounds[1].They aslo are witnessing significant prominence in medicinal chemistry discovery programs,and the various reports that have documented the benefits accompanying their use in discovery candidates are driving the increased visibility.The range of advantages includes structural novelty along with improved physicochemical and pharmaco-kinetic properties[2].More and more lead compounds containing cyclobutane skeletons have been designed, synthesized and separated[3-7].

Since the proposition of the correct structure of pyridine by Kner (1869) and Dewar (1871),this ring really became one of the most studied aromatics[1].To date, pyridines are among the most prevalent heterocyclic structural units in pharmaceutical and agrochemical targets, as well as in materials science.Pyridines also provide convenient synthetic precursors to chiral dihydro- and tetrahydropyridines,as well as piperidines, which continue to be of interest as intermediates in alkaloid synthesis,in NADH models, and as important biologically active structures[2-7].