Standards; Chiral Molecules; Molecular Biology; Pharmaceutical/API Drug Impurities/Metabolites;
应用
(αS)-2-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2S)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide is an impurity of Carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
参考文献
Hoeferl-Prantz, K. & Wilhelm, T.: PCT Int. Appl. 104pp. Patent (2015) CODEN:PIXXD2; Dehury, S., et. al.: PCT Int. Appl. 101pp. Patent (2016) CODEN:PIXXD2; Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);
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