Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
应用
Leptomycin B is a Streptomyces metabolite that inhibits nuclear export of the human immunodeficiency virus type 1 regulatory protein Rev at low nanomolar concentrations. It covalently binds to cysteine residue in the center of CRM1/exportin 1 protein.
参考文献
Kudo, N., et al.: Exp. Cell. Res., 242, 540 (1998); Kudo, N., et al.: Proc. Natl. Acad. Sci. USA, 96, 9112 (1999);