New Building Blocks for January 20202020/1/19 10:34:54
The four-membered oxetane ring has been increasingly exploited for its contrasting behaviors: its influence on physicochemical properties as a stable motif in medicinal chemistry and its propensity to undergo ring-opening reactions as a synthetic intermediate. Examples of the use of oxetanes in medicinal chemistry are reported[2,3,4,5].
These applications have driven numerous studies into the synthesis of new oxetane derivatives.
A series of medicinal products containing oxetane has been firmly incorporated in medical practice.