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New Building Blocks for December 2019 2019/12/27 16:09:23

               新品推荐 - 2019年12月                
Building Blocks  /  Pharmaceutical Intermediates  /  Chemical Reagents
Azetidines are an important class of aza-heterocyclic compounds with remarkable biological activities,                              which makes them an interesting scaffold in the field of medicinal chemistry[1].                              In recent years, structure-activity studies of many drugs or bioactive compounds have shown that the azetidine ring has a wide range of applications as a pharmacological tool.                              Moreover, the number of recent manuscripts gives evidence of the large use of this ring system in the synthesis of bioactive compounds[2-6].
Azetidines
A series of medicinal products containing azetidine
                             has been firmly incorporated in medical practice.
[1] Chem. Rev. 2008, 108, 3988?4035.
                             [2] ACS Med. Chem. Lett. 2019, 10, 1524?1529.
                             [3] Bioorg. Med. Chem. 2019, 27, 3568–3573.
                             [4] J. Med. Chem. 2019, 62, 3336?3353.
                             [5] Bioorg. Med. Chem. Lett. 2019, 29, 873–877.
                             [6] J. Med. Chem. 2017, 60, 9508?9530.
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