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Azetidines are an important class of aza-heterocyclic compounds with remarkable biological activities, which makes them an interesting scaffold in the field of medicinal chemistry. In recent years, structure-activity studies of many drugs or bioactive compounds have shown that the azetidine ring has a wide range of applications as a pharmacological tool. Moreover, the number of recent manuscripts gives evidence of the large use of this ring system in the synthesis of bioactive compounds[2-6].
A series of medicinal products containing azetidine has been firmly incorporated in medical practice.