1H-Indazoles are incredibly rare in nature but the diverse pharmacological properties imparted to molecules containing this nucleus has catapulted them firmly into the drug designer’s toolkit[1]. Indeed, molecules presenting the 1H-indazole motif are widely incorporated in multiple drugs such as anti-HIV, anti-inflammatory and anti-cancer drugs[2], and many examples have been proved that 1H-Indazoles have featured in the development of drugs spanning a range of pathophysiologies, such as bendazac (anti-inflammation) and axitinib (anti-cancer) as well as gamendazole (a drug candidate for male contraception)[1, 3-5].
[1] Tetrahedron Letters (2019), 60(37), 150929-150932.
[2] Chemical Science (2017), 8(2), 1303-1308.
[3] European Journal of Medicinal Chemistry (2010), Volume Date2011, 46(1), 168-174.
[4] Molecules (2018), 23(11), 2783/1-2783/41.
[5] Organic Process Research & Development (2008), 12(5), 877-883.
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