最新药物分子砌块-2020/11 2020/11/15 11:05:43

新品推荐 - 2020 年 11 月

有机合成砌块、合成试剂、特色医药中间体

快乐科研 品质之选

The pyrazine unit is an important structural motif that widely existed in many bioactive and nature compounds.[1] Pyrazine derivatives have attracted wide pharmaceutical interests because of their potential uses in the treatment of psychiatric disorders, neurological diseases (e.g., stress, anxiety and depression), and cardiovascular disorders.[2] They are reported to modulate the activity of CRF1 (corticotropin-releasing factor 1) receptors. Besides, they are also versatile building blocks in the synthesis of VCAM-1 (vascular cell adhesion molecule-1) inhibitors, pyrazine alkaloids (antineoplasmic activity), and imidazopyrazin coelenterazine (bioluminescent). [2] In recent years, pyrazine scaffold has been found in more and more drug molecules.[3-7]

A series of medicinal products containing pyrazine has been firmly incorporated in medical practice.
A series of medicinal products containing pyrazine has been firmly
incorporated in medical practice.

[1] Advanced Synthesis & Catalysis (2020), 362(17), 3621-3626.
[2] Tetrahedron Letters (2009), 50(14), 1618-1621.
[3] Journal of Medicinal Chemistry (2020), Ahead of Print.DOI: 10.1021/acs.jmedchem.0c01170
[4] Journal of Medicinal Chemistry (2015), 58(17), 6753-6765.
[5] Journal of Medicinal Chemistry (2015), 58(13), 5344-5354.
[6] Journal of Medicinal Chemistry (2018), 61(5), 1821-1832.
[7] Journal of Medicinal Chemistry (2018), 61(13), 5525-5546.

  • 5780-66-5

    产品编号: 1062046

    CAS: 5780-66-5

  • 39204-49-4

    产品编号: 1069755

    CAS: 39204-49-4

  • 1049026-49-4

    产品编号: 1068198

    CAS: 1049026-49-4

  • 1965308-99-9

    产品编号: 1172725

    CAS: 1965308-99-9

  • 23688-89-3

    产品编号: 1062568

    CAS: 23688-89-3

  • 54237-53-5

    产品编号: 1062566

    CAS: 54237-53-5

  • 937669-80-2

    产品编号: 1066550

    CAS: 937669-80-2

  • 84996-40-7

    产品编号: 1168279

    CAS: 84996-40-7

  • 63286-28-2

    产品编号: 1038583

    CAS: 63286-28-2

  • 356783-16-9

    产品编号: 1049192

    CAS: 356783-16-9

  • 1260667-67-1

    产品编号: 1112706

    CAS: 1260667-67-1

  • 1458-16-8

    产品编号: 1088709

    CAS: 1458-16-8

  • 925678-00-8

    产品编号: 1118028

    CAS: 925678-00-8

  • 1166827-49-1

    产品编号: 1060028

    CAS: 1166827-49-1

  • 81166828-19-8

    产品编号: 1060030

    CAS: 1166828-19-8

  • 1458-18-0

    产品编号: 1062840

    CAS: 1458-18-0

免费热线:400-821-0725

官方网址: www.leyan.com 技术支持邮箱: tech@leyan.com.cn 产品咨询邮箱: product@leyan.com.cn

声明:乐研产品仅用于科学研究,我们不为任何个人用途提供产品与服务。

上一篇:实验人员看过来,乐研样品瓶上新啦! 下一篇:New Building Blocks for June 2020


40000+分子砌块

现货供应

10年研发经验

专业护航

10天无理由退换

售后无忧

100%质量检测

品质保障

100%产品包邮

无需凑单