最新药物分子砌块-2020/10 2020/10/22 11:05:43

新品推荐 - 2020 年 10 月

有机合成砌块、合成试剂、特色医药中间体

快乐科研 品质之选

Pyrimidines are the key skeletons in numerous bioactive compounds and natural products[1]. A pyrimidine has many properties, electrophilic aromatic substitution gets more difficult while nucleophilic aromatic substitution gets easier[2]. In particular, a variety of pyrimidine-derived drugs have demonstrated interesting biological activities such as cyclin-dependent kinases (CDK), tumor necrosis factor α (TNF-α), ableson protein tyrosine kinase (Abl), 3-phosphatidylinositol kinases (PI-3K), protein kinase B (Akt kinase), cytokines inhibitors[1, 3] and so on[4-7]. Over a century, pyrimidine derivatives are important azaheterocycles that have inspired the development of new methodologies for their chemical synthesis[2].

A series of medicinal products containing imidazo[1,5-a]pyridine has been firmly incorporated in medical practice.
A series of medicinal products containing pyrimidine has been firmly
incorporated in medical practice.

[1] Organic Letters (2020), 22(14), 5645-5649.
[2] Journal of Heterocyclic Chemistry (2020), Ahead of Print. DOI: 10.1002/jhet.4070.
[3] Journal of Medicinal Chemistry (2011), 54(9), 3200-3205.
[4] Journal of Medicinal Chemistry (2016), 59(15), 7268-7274.
[5] Journal of Medicinal Chemistry (2020), Ahead of Print. DOI:
[6] Journal of Medicinal Chemistry (2019), 62(22), 10376-10390.
[7] European Journal of Medicinal Chemistry (2019), 163, 169-182.

  • 2435-50-9

    产品编号: 1062207

    CAS: 2435-50-9

  • 31575-35-6

    产品编号: 1065484

    CAS: 31575-35-6

  • 25198-95-2

    产品编号: 1069157

    CAS: 25198-95-2

  • 22930-71-8

    产品编号: 1177037

    CAS: 22930-71-8

  • 1308298-23-8

    产品编号: 1061747

    CAS: 1308298-23-8

  • 2164-65-0

    产品编号: 1068158

    CAS: 2164-65-0

  • 1235451-38-3

    产品编号: 1069784

    CAS: 1235451-38-3

  • 849353-34-0

    产品编号: 1114390

    CAS: 849353-34-0

  • 1206459-86-0

    产品编号: 1172733

    CAS: 1206459-86-0

  • 1523618-18-9

    产品编号: 1191204

    CAS: 1523618-18-9

  • 663193-80-4

    产品编号: 1052856

    CAS: 663193-80-4

  • 60186-89-2

    产品编号: 1066486

    CAS: 60186-89-2

  • 71406-78-5

    产品编号: 1069460

    CAS: 71406-78-5

  • 944401-58-5

    产品编号: 1111781

    CAS: 944401-58-5

  • 84332-06-9

    产品编号: 1183427

    CAS: 84332-06-9

  • 959070-42-9

    产品编号: 1052989

    CAS: 959070-42-9

免费热线:400-821-0725

官方网址: www.leyan.com.cn 技术支持邮箱: tech@leyan.com.cn 产品咨询邮箱: product@leyan.com.cn

声明:乐研产品仅用于科学研究,我们不为任何个人用途提供产品与服务。

上一篇:实验人员看过来,乐研样品瓶上新啦! 下一篇:New Building Blocks for June 2020


40000+分子砌块

现货供应

10年研发经验

专业护航

10天无理由退换

售后无忧

100%质量检测

品质保障

100%产品包邮

无需凑单